Allergan, Plc
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| Acquired by Pfizer | |
| Traded as | NYSE: AGN S&P 500 Component |
| Industry | Branded and generic pharmaceuticals, and pharmaceutical research and development. |
| Founded | Est 2015 through the acquisition of Allergan, Inc by Actavis, Plc |
| Founder | Allen Chao, Ph.D. and David Hsia, Ph.D. |
| Headquarters | Dublin, Ireland and Parsippany-Troy Hills, New Jersey, United States. |
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Number of locations
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40 manufacturing facilities, 27 global R&D centers and marketing/sales facilities worldwide. |
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Area served
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~100 Countries |
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Key people
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Paul Bisaro, Executive Chairman, Brenton L. Saunders President and CEO |
| Products | Branded and generic pharmaceuticals |
| Revenue | US$ 4.2 billion(Q1 2015) [1] |
 US$ 1.090 billion (2014) |
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 -US$ 1.630 billion (2014) |
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| Total assets | US$ 6.881 billion (2014) |
| Total equity | US$ 28.335 billion (2014) |
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Number of employees
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30,000 (June 2015) |
| Website | www |
On February 18, 2015, the company formerly known as Actavis, Plc announced its intention to change its name to Allergan, Plc. This was completed as of June 15, 2015. Actavis, Plc then became Actavis which now forms the US Generics division of the company.[2][3]
Contents
Corporate history[edit]
2015[edit]
After the acquisition of Allergan, Inc by Actavis, Plc, the new company made its first acquisition on July 6, when the company acquired start-up, Oculeve, for $125 million.[4] On July 7 the company announced it would acquire Merck & Cos late stage CGRP migraine portfolio, as well as two experimental drugs (MK-1602 and MK-8031) for $250 million.[5] In July, Allergan agreed to sell off its small molecule generic drug business, not including its biosimilars business, to Teva Pharmaceutical Industries for $40.5 billion ($33.75 billion in cash and $6.75 billion worth of shares).[6][7] A day later, the company announced it would acquire Naurex Inc for $560 million with more tied to regulatory milestones.[8][9] In September the company announced it would acquire ophthalmic device start-up AqueSys for $300 million plus future sums tied to approval/sales milestones.[10] In November the company acquired aesthetic device company Northwood Medical Innovation[11]
Pfizer[edit]
In late October The Wall Street Journal reported that merger talks between Allergan and Pfizer were in early phases, with Pfizer approaching Allergan due to an industry-wide drop in share prices. Any merger with Allergan would then also give Pfizer the ability to re-domicile to Ireland, taking advantage of its lower tax rates.[12][13] On 23 November, 2015, the two companies announced their intention to merge for an approximate sum of $160 billion making this the largest pharmaceutical deal ever and the third largest merger in history. As part of the deal, Pfizer CEO Ian Read will remain CEO and Chairman of the combined company (to be called Pfizer Plc), with Allergan CEO, Brent Saunders, becoming President and Chief operating officer. As part of the deal Allergan shareholders will receive 11.3 shares of the company, with Pfizer shareholders receiving one.[14]
Company evolution[edit]
Acquisition history[edit]
The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):
| Allergan, Plc (formerly known as Actavis until June 2015 when it adopted Allergans name) |
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Key Products[edit]
- Actonel (risedronic acid) for the treatment or prevention osteoporosis, and for Paget's disease of bone treatment
- Acuvail (ketorolac ophthalmic solution) for the treatment of pain and inflammation following cataract surgery
- Aczone (dapsone gel) for acne
- Alphagan P (brimonidine ophthalmic solution) for glaucoma
- Androderm CIII (testosterone transdermal system) for replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone
- Asacol HD (mesalamine extended release) for moderately active ulcerative colitis
- Atelvia (risedronic acid delayed release) for the treatment of osteoporosis in postmenopausal women
- Avycaz (ceftazidime/avibactam) for complicated intra-abdominal infections (in combination with metronidazole)
- Botox (onabotulinumtoxinA) for various spasms and dystonias
- Botox Cosmetic/Vistabel (onabotulinumtoxinA)—anti-wrinkle cosmetic drug derived from Botox
- Bystolic (nebivolol) for hypertension
- Combigan (brimonidine/timolol) for glaucoma
- Crinone (progesterone gel) for progesterone supplementation or replacement as part of an assisted reproductive technology (ART) treatment for infertile women with progesterone deficiency
- Dalvance (dalbavancin) for acute bacterial skin and skin structure infections (ABSSSI)
- Delzicol (mesalamine extended release) for mildly-to-moderately active ulcerative colitis
- Doryx (doxycycline hyclate extended release)—a tetracycline-class antimicrobial
- Enablex (darifenacin extended release) for overactive bladder
- Estrace (estradiol vaginal cream) for vulvar and vaginal atrophy due to menopause
- Fetzima (levomilnacipran extended release) for major depressive disorder
- Gelnique (oxybutynin gel) for overactive bladder
- Juvéderm injectable gel (cross-linked hyaluronic acid)—dermal filler
- Lastacaft (alcaftadine ophthalmic solution) for the prevention of itching associated with eye allergies
- Latisse (bimatoprost ophthalmic solution) for hypotrichosis of the eyelashes
- Liletta (levonorgestrel-releasing intrauterine system) for contraception
- Linzess (linaclotide) for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation—co-marketed with Ironwood Pharmaceuticals
- Lo Loestrin Fe (norethindrone and ethinyl estradiol; ethinyl estradiol; ferrous fumarate) for contraception
- Lumigan (bimatoprost ophthalmic solution) for glaucoma
- Namenda (memantine) for moderate-to-severe dementia of the Alzheimer's type
- Namenda XR (memantine extended release) for moderate-to-severe Alzheimer's disease
- Namzaric (memantine extended release/donepezil) for moderate-to severe-Alzheimer's disease in patients who are currently taking and can continue to take certain doses of both Namenda or Namenda XR (see above) and donepezil
- Natrelle—breast implants (silicone and saline)
- Ozurdex (dexamethasone intravitreal implant) for branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO)
- Orbera system—an intragastric balloon, inserted endoscopically; designed to assist weight loss by partially filling the stomach and inducing satiety for overweight patients with a body mass index (BMI) of 27 or greater
- Rapaflo (silodosin) for benign prostatic hyperplasia
- Restasis (ciclosporin ophthalmic emulsion) for dry eye syndrome
- Saphris (asenapine sublingual tablets) for schizophrenia and bipolar I disorder
- Skinmedica—facial line
- Tazorac (tazarotene) for acne and psoriasis.
- Teflaro (ceftaroline fosamil) for community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI)
- Viberzi (eluxadoline) for diarrhea-predominant irritable bowel syndrome (IBS-D)
- Viibryd (vilazodone) for major depressive disorder
- Zenpep (pancrelipase) for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, or other conditions
References[edit]
- ^ TheStreet Transcripts. "Actavis (ACT) Earnings Report: Q1 2015 Conference Call Transcript". The Street.
- ^ Calia, Michael (2015-02-18). "Actavis Adopting Allergan Name; Earnings Soar as Closing of Deal Looms". WSJ. Retrieved 2015-02-19.
- ^ Haggerty, Neil (2015-06-15). "Actavis Changes Name to Allergan After Deal For Botox Maker". WSJ. Retrieved 2015-06-15.
- ^ "Allergan bets $125M on a new approach to dry eye disease". FierceBiotech.
- ^ "UPDATED: Bowing out of crowded race, Merck sells a migraine drug to Allergan for $250M". FierceBiotech.
- ^ Cynthia Koons (27 July 2015). "Teva CEO: $40.5 Billion Allergan Deal is Just the Beginning - Bloomberg Business". Bloomberg.com.
- ^ Chitra Somayaji (27 July 2015). "Teva Snaps Up Allergan’s Generics Arm, Dumping Mylan". Bloomberg.com.
- ^ "Allergan joins the hunt for a 'transformational' biotech deal". FierceBiotech.
- ^ "UPDATED: Allergan bags NMDA depression drugs in $560M-plus Naurex buyout". FierceBiotech.
- ^ "Allergan to grab AqueSys for $300M+ to add minimally invasive glaucoma microshunt". FierceMedicalDevices.
- ^ "Allergan beefs up in aesthetics with implant purchase. Does M&A suitor Pfizer approve?". FierceMedicalDevices.
- ^ Jonathan D. Rockoff, Dana Mattioli and Dana Cimilluca (29 October 2015). "Pfizer and Allergan Begin Merger Talks". WSJ.
- ^ Ed Hammond (29 October 2015). "Pfizer, Allergan Said to Discuss Record Pharmaceutical Deal". Bloomberg.com.
- ^ "Pfizer seals $160bn Allergan deal to create drugs giant". BBC News.
