Balding–Nichols model
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In population genetics, the Balding–Nichols model is a statistical description of the allele frequencies in the components of a sub-divided population.[1] With background allele frequency p the allele frequencies, in sub-populations separated by Wright's FST F, are distributed according to independent draws from
where B is the Beta distribution. This distribution has mean p and variance Fp(1 – p).[2]
The model is due to David Balding and Richard Nichols and is widely used in the forensic analysis of DNA profiles and in population models for genetic epidemiology.
References[edit]
- ^ Balding, DJ; Nichols, RA (1995). "A method for quantifying differentiation between populations at multi-allelic loci and its implications for investigating identity and paternity.". Genetica (Springer) 96: 3–12. doi:10.1007/BF01441146. PMID 7607457.
- ^ Alkes L. Price, Nick J. Patterson, Robert M. Plenge, Michael E. Weinblatt, Nancy A. Shadick & David Reich (2006). "Principal components analysis corrects for stratification in genome-wide association studies" (PDF). Nature Genetics 38 (8): 904–909. doi:10.1038/ng1847. PMID 16862161.
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