Insect repellent

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A mosquito coil

An insect repellent (also commonly called "bug spray") is a substance applied to skin, clothing, or other surfaces which discourages insects (and arthropods in general) from landing or climbing on that surface. Insect repellents help prevent and control the outbreak of insect-borne diseases such as malaria, Lyme disease, dengue fever, bubonic plague, and West Nile fever. Pest animals commonly serving as vectors for disease include insects such as flea, fly, and mosquito; and the arachnid tick.

Common insect repellents[edit]

Oil Jar in cow horn for mosquito-repelling pitch oil, a by-product of the distillation of wood tar. Carried in a leather strap on a belt. Ranea, Norrbotton, since 1921 in Nordiska museet, Stockholm.[1]
  • Birch tree bark is traditionally made into tar. Combined with another oil (e.g., fish oil) at 1/2 dilution, it is then applied to the skin for repelling mosquitos[2][3][4]
  • DEET (N,N-diethyl-m-toluamide)
  • Essential oil of the lemon eucalyptus (Corymbia citriodora) and its active compound p-menthane-3,8-diol (PMD)
  • Icaridin, also known as picaridin, Bayrepel, and KBR 3023
  • Nepetalactone, also known as "catnip oil"
  • Citronella oil[5]
  • Neem oil
  • Bog Myrtle (Myrica Gale)
  • Dimethyl carbate
  • Tricyclodecenyl allyl ether, a compound often found in synthetic perfumes.[6][7]
  • IR3535 (3-[N-Butyl-N-acetyl]-aminopropionic acid, ethyl ester)
  • Ethylhexanediol, also known as Rutgers 612 or "6-12 repellent," discontinued in the US in 1991 due to evidence of causing developmental defects in animals[8]
  • Dimethyl phthalate, not as common as it once was but still occasionally an active ingredient in commercial insect repellents
  • Metofluthrin
  • Indalone. Widely used in a "6-2-2" mixture (60% Dimethyl phthalate, 20% Indalone, 20% Ethylhexanediol) during the 1940s and 1950s before the commercial introduction of DEET.
  • Permethrin is different in that it is actually a contact insecticide.
  • A more recent repellent being currently researched is SS220, which has been shown to provide significantly better protection than DEET.
  • Another new and promising group of repellents are the anthranilate-based insect repellents.

Repellent effectiveness[edit]

A popular post-WWII Australian brand of insect repellent.

Synthetic repellents tend to be more effective and/or longer lasting than "natural" repellents.[9][10] In comparative studies, IR3535 was as effective or better than DEET in protection against mosquitoes.[11] Other sources (official publications of the associations of German physicians[12] as well as of German drugists[13] suggest the contrary and state DEET is still the most efficient substance available and the substance of choice for stays in malaria regions, while IR3535 has little effect. However, some plant-based repellents may provide effective relief as well.[9][10][14] Essential oil repellents can be short-lived in their effectiveness, since essential oils can evaporate completely.

A test of various insect repellents by an independent consumer organization found that repellents containing DEET or picaridin are more effective than repellents with "natural" active ingredients. All the synthetics gave almost 100% repellency for the first 2 hours, where the natural repellent products were most effective for the first 30 to 60 minutes, and required reapplication to be effective over several hours.[15]

For protection against mosquitos, the U.S. Centers for Disease Control (CDC) issued a statement in May 2008 recommending equally DEET, picaridin, oil of lemon eucalyptus and IR3535 for skin.[16] Permethrin is recommended for clothing, gear, or bed nets.[9] In an earlier report, the CDC found oil of lemon eucalyptus to be more effective than other plant-based treatments, with a similar effectiveness to low concentrations of DEET.[17] However, a 2006 published study found in both cage and field studies that a product containing 40% oil of lemon eucalyptus was just as effective as products containing high concentrations of DEET.[18] Research has also found that neem oil is mosquito repellent for up to 12 hours.[14] Citronella oil's mosquito repellency has also been verified by research,[19] including effectiveness in repelling Aedes aegypti,[20][21] but requires reapplication after 30 to 60 minutes.

There are also products available based on sound production, particularly ultrasound (inaudibly high frequency sounds) which purport to be insect repellents. However, these electronic devices have been shown to be ineffective based on studies done by the EPA and many universities.[22]

Repellent safety[edit]

DEET
Icaridin
p-Menthane-3,8-diol (PMD)

Regarding safety with insect repellent use on children and pregnant women:

  • Children may be at greater risk for adverse reactions to repellents, in part, because their exposure may be greater.
  • Keep repellents out of the reach of children.
  • Do not allow children to apply repellents to themselves.
  • Use only small amounts of repellent on children.
  • Do not apply repellents to the hands of young children because this may result in accidental eye contact or ingestion.
  • Try to reduce the use of repellents by dressing children in long sleeves and long pants tucked into boots or socks whenever possible. Use netting over strollers, playpens, etc.
  • As with chemical exposures in general, pregnant women should take care to avoid exposures to repellents when practical, as the fetus may be vulnerable.

Regardless of which repellent product used, it is recommended to read the label before use and carefully follow directions.[23] Usage instructions for repellents vary from country to country. Some insect repellents are not recommended for use on younger children.[16]

In the DEET Reregistration Eligibility Decision (RED) the United States Environmental Protection Agency (EPA) reported 14 to 46 cases of potential DEET associated seizures, including 4 deaths. The EPA states: "... it does appear that some cases are likely related to DEET toxicity," but observed that with 30% of the US population using DEET, the likely seizure rate is only about one per 100 million users.[24]

The Pesticide Information Project of Cooperative Extension Offices of Cornell University states that, "Everglades National Park employees having extensive DEET exposure were more likely to have insomnia, mood disturbances and impaired cognitive function than were lesser exposed co-workers".[25]

The EPA states that citronella oil shows little or no toxicity and has been used as a topical insect repellent for 60 years. However, the EPA also states that citronella may irritate skin and cause dermatitis in certain individuals.[5] Canadian regulatory authorities concern with citronella based repellents is primarily based on data-gaps in toxicology, not on incidents.[26][27]

Within countries of the European Union, implementation of Regulation 98/8/EC,[28] commonly referred to as the Biocidal Products Directive, has severely limited the number and type of insect repellents available to European consumers. Only a small number of active ingredients have been supported by manufacturers in submitting dossiers to the EU Authorities.

In general, only formulations containing DEET, icaridin (sold under the trade name Saltidin and formerly known as Bayrepel or KBR3023), IR3535 (3-[N-Butyl-N-acetyl]-aminopropionic acid, ethyl ester) and Citriodiol (p-menthane-3,8-diol) are available. Most "natural" insect repellents such as citronella, neem oil, and herbal extracts are no longer permitted for sale as insect repellents in the EU; this does not preclude them from being sold for other purposes, as long as the label does not indicate they are a biocide (insect repellent).

Insect repellents from natural sources[edit]

There are many preparations from naturally occurring sources that have been used as a repellent to certain insects. Some of these act as insecticides while others are only repellent.

Inactive substances – carriers[edit]

In 2002, the New England Journal of Medicine[52] published an article that found products containing essential oils such as catnip[53] or geranium oil, when combined with a suitable carrier oil such as soybean, have been found to be effective as natural repellents. This was based on testing done by Johns Hopkins[54] and Cornell Universities.[55] Other commercial products offered for household mosquito "control" include small electrical mats, mosquito repellent vapor, DEET-impregnated wrist bands, mosquito fogging, and mosquito coils containing a form of the chemical allethrin. Mosquito-repellent candles containing citronella oil are sold widely in the U.S. These have been used with mixed reports of success and failure.[56]

Less effective methods[edit]

Some old studies suggested that the ingestion of large doses of thiamine could be effective as an oral insect repellent against mosquito bites. However, there is now conclusive evidence that thiamin has no efficacy against mosquito bites.[57][58][59][60] Some claim that plants like wormwood or sagewort, lemon balm, lemon grass, lemon thyme and the mosquito plant (Pelargonium) will act against mosquitoes. However, scientists have determined that these plants are “effective” for a limited time only when the leaves are crushed and applied directly to the skin.[61]

There are several, widespread, unproven theories about mosquito control, such as the assertion that vitamin B, in particular B1 (thiamine), garlic, ultrasonic devices or incense can be used to repel or control mosquitoes.[58][62] Moreover, manufacturers of "mosquito repelling" ultrasonic devices have been found to be fraudulent,[63] and their devices were deemed "useless" in tests by the UK Consumer magazine Which?,[64] and according to a review of scientific studies.[65]

See also[edit]

References[edit]

  1. ^ Comparisons explanatory text in the display: https://commons.wikimedia.org/wiki/File:Oil_Jar_in_cow_horn_for_mosquito-repelling_pitch_oil.JPG
  2. ^ Happy people: A year in the Taiga
  3. ^ Making birch bark tar
  4. ^ Birch bark used as mosquito repellent
  5. ^ a b "Citronella (Oil of Citronella) (021901) Fact Sheet". United States Environmental Protection Agency. 16 February 2011. Retrieved 1 July 2011. 
  6. ^ Insect Repellents - Patent 6660288
  7. ^ Detailed patent information
  8. ^ Brown, Maryland Extension Service leaflet 10
  9. ^ a b c M. S. Fradin and J. F. Day (2002). "Comparative Efficacy of Insect Repellents against Mosquito Bites". N Engl J Med 347 (1): 13–18. doi:10.1056/NEJMoa011699. PMID 12097535. 
  10. ^ a b Collins, D.A.; Brady, J.N.; Curtis, C.F. (1993). "Assessment of the efficacy of Quwenling as a Mosquito repellent". Phytotherapy Research 7 (1): 17–20. doi:10.1002/ptr.2650070106. 
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  16. ^ a b "Updated Information regarding Insect Repellents". Centers for Disease Control and Prevention. 8 May 2008. 
  17. ^ "Insect Repellent Use and Safety". West Nile Virus. Centers for Disease Control and Prevention. 12 January 2007. 
  18. ^ Carroll SP, Loye J, 2006, Journal of the American Mosquito Control Association 22(3):507-514, 510
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External links[edit]

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