Key attributes of registered COVID-19 vaccine trials
Living review
Published data on safety, immunogenicity and efficacy
Last updated on
01 September 2020.
We currently update the vaccine landscape weekly, pooling the latest information from the
WHO,
the
Milken Institute
and
clinicaltrials.gov.
We are also grateful for additional information provided directly by vaccine developers.
For a copy of the database, or to inform us of a candidate that is not included, please contact
vaccines@lshtm.ac.uk.
Each week, we search
clinicaltrials.gov
for studies of COVID-19 vaccine candidates and extract key attributes from the registered protocols.
Additional trials are identified using the
WHO COVID-19 vaccine landscape.
Trials are listed by decreasing size.
aAPC: artificial antigen presenting cell;
AZLB: Anhui Zhifei Longcom Biopharmaceutical;
BIBP: Beijing Institute of Biological Products;
CAMS: Chinese Academy of Medical Sciences;
FBRI SRC VB: Federal Budgetary Research Institution State Research Center of Virology and Biotechnology;
KBP: Kentucky BioProcessing;
LV-SMENP-DC: vaccine comprising dendritic cells (DCs) modified with lentivirus (LV) vectors expressing 'SMENP' minigene;
PLA-AMS: People's Liberation Army Academy of Military Science;
SGMI: Shenzhen Geno-Immune Medical Institute;
WIBP: Wuhan Institute of Biological Products.
This living review summarises the available clinical trial data on different COVID-19 vaccine candidates.
Since 24 August 2020, we have performed a weekly search of
medRxiv
and
PubMed
(see
Search log
below) using the R packages
medrxivr
and
easyPubMed.
Titles and abstracts are screened to identify articles reporting outcome data from human clinical trials of COVID-19 vaccine candidates.
Search term
"(coronavirus OR COVID OR SARS*) AND vaccin* AND (trial OR phase)"
Data extraction
We extract data on the following study attributes:
Design:
location, number and age of individuals enrolled, vaccine dose, etc
Safety profile:
serious adverse events as well as non-serious adverse events with ≥25% prevalence
Immunogenicity:
pre- and post-vaccination levels of antigen-specific IgG (ELISA), neutralising antibody levels against live SARS-CoV-2 and/or pseudoviruses, and/or T-cell responses.
We present antibody and T-cell outcomes 28 days post-vaccination or the nearest available timepoint, where available.
Efficacy:
protective efficacy against COVID-19 (not reported for any trials published to date).
Planned next steps
for clinical testing and/or manufacture.
Search log
Eligible studies
Abbreviations:
WIBP: Wuhan Institute of Biological Products.
Notes:
Phase I and phase II data for WIBP inactivated vaccine extracted separately (Xia; JAMA 2020).
Description of vaccine
Trial attributes
Safety profile
We present data on any
serious adverse events
(potentially life-threatening: requires assessment in A&E or hospitalisation) and
common adverse events
(≥25% prevalence) relating to the test vaccine.
Serious adverse events:
Common adverse events (local): Common adverse events (systemic):
Antibody response
We present antibody levels measured 28 days post-vaccination or the nearest available timepoint.
Where multiple types of antibody were measured, we prioritise (i) ELISA for the vaccine-specific antigen;
(ii) neutralisation of live SARS-CoV-2; and (iii) neutralisation of a pseudovirus modified to express SARS-CoV-2 antigens.